CurcuminForte Balance® is a nutritional supplement made from anti- inflammatory herbal extracts .
CurcuminForte Balance has been carefully formulated with just the right mix of concentrated herb extracts. These extracts work in synergy to achieve optimum anti-inflammatory results.
This supplement can then be taken alongside conventional medicine and should provide greater relief for sufferers of colitis. If you suffer from ulcerative colitis then read on to discover a natural, scientifically-proven way to reduce your symptoms and increase your quality of life.
The scientists behind H. Plant Extract developed the CurcuminForte Balance formula based on scientific research.
The formula is made in Israel and contains:
- Curcumin, the active agent of the turmeric rhizome.
- Extract of pomegranate rind (rich in Ellagic acid)
- Piperine, the active agent in black pepper
In order to verify the medicinal properties of the above ingredients and highlight their role in treating colitis, we present below a brief summary of recent which explains their therapeutic effect.
The Effects of Curcumin on Colitis
Curcumin. the active agent of the turmeric rhizome, is well-known for its therapeutic qualities. It has been used for centuries across the globe and recent scientific research is verifying its role in treating inflammatory diseases, including Colitis. See below for two research articles on the effect of curcumin on Colitis.
Japanese researchers studied the ‘maintenance therapy' effect of curcumin during the dormant period of ulcerative colitis. Their research found that the use of curcumin significantly decreased the relapse rate of patients (2) versus the placebo group (8) and also improved the clinical activity index (which measures disease activity).
The research lasted 6 months and included the study of 89 patients with quiescent ulcerative colitis.
The results showed that only 2 participants from the first group suffered from a relapse (4.6%) as opposed to 8 participants from the second group who took a placebo (20.5%).
At the end of this experiment the researchers continued to track the participants for a further 6 months. During this period all participants ceased taking the additional curcumin or placebo and continued taking their standard medication only, either sulfasalazine or mesalamine.
During the follow-up period, 8 patients from the curcumin group and 6 from the placebo group suffered a relapse.
The conclusion of the researchers was that curcumin is a safe supplement that helps to maintain remission in patients with quiescent ulcerative colitis.
The outcome of this research inspired another research study. Researchers at Steele Children's Research Center at the University of Arizona proved that curcumin reduces the intensity of inflammation and as a result reduces bowl damage in patients with Inflammatory Bowel Disease (IBD). This would also help those with Crohn’s and Ulcerative Colitis, which are the most common forms of IBD.
During the study, which lasted a few years, the researchers succeeded in identifying curcumin's mechanism of action in treating IBD. (1)
The Mechanism of Action of Curcumin in treating Colitis
‘Mechanism of action’ is a pharmacological term referring to how a substance exerts its effects on cells or tissues.
Neutrophils are white blood cells that have great significance in the activity of the immune system. They are the first to identify pathogens (infection generators) and then to fight and annihilate them.
Dr Pawel Kiela stated that “Under normal circumstances, neutrophils (white cells) are indispensible for fighting infection and resolving the inflammation. But with IBD, there is an exaggerated and prolonged influx of neutrophils into the inflamed tissue. Paradoxically, then, the neutrophils end up damaging the lining of the intestines, making the inflammation even worse. In the end, this innate response designed to aid in the fighting of pathogens ends up causing more harm than good.”
The Study found that Curcumin inhibits the neutrophils' migration to the infected area and by doing so decreases the damage to the bowels.
In summary the researchers claim that curcumin can't replace the existing traditional medicinal treatment but it is a valuable nutritional supplement which can improve the quality of life for ulcerative colitis patients. 
Research conducted in Shiba Tel Hashomer Medical Hospital tested ulcerative cell samples and found that exposure to Curcumin leads to:
- 70% inhibition of differentiation of the lymphocytes CD4. These are the cells in the immune system that take part in the inflammatory process.
- 98% increase in the apoptosis, death of these cells.
- Significant inhibition (80%) of the activity of pro- inflammatory mediators: Cytokines, TNF alpha and IL-8.
The research was carried out on humans and focused mainly on the combined treatment of Curcumin and conventional drugs.
Curcumin's bioavailability is low, this means that it is secreted very quickly from the body and has no time to work its magic. In order to overcome this issue Curcumin should be combined with piperine, the active agent in black pepper. Research carried out in Japan shows that a small dosage of piperine increases the bioavailability of curcumin by 2000%!!
Piperine is not only a natural enhancer but is also a strong anti-inflammatory and powerful antioxidant. In recent years there has been more and more research on piperine and its contribution in treating inflammatory diseases.
Piperine helps treating Colitis
The treatment with piperine lead to significant improvement in the disease activity index. It:
- suppressed weight loss, diarrhea, gross bleeding and infiltration of immune cells.
- effectively and dose-dependently prevented the shortening of the colon length and enlargement of the spleen size.
Histological examination indicates that piperine reduces swelling, hemorrhages and ulceration. Furthermore, piperine administration leads to inhibition of pro-inflammatory mediators.
The researched concluded, "These results suggest that piperine has an anti-inflammatory effect at colorectal sites…..[and] may have therapeutic potential on amelioration of IBD." 
An article by a group of researchers from Brazil, about the latest trends in treating Colitis with alkaloids (of which Piperine is one), was published in The Journal Evidence-Based Complementary and Alternative Medicine (January 2017). According the researchers, about one third of colitis patients do not respond to conventional medication and therefore there is need to find alternatives. Piperine is one solution to consider.
According to Chinese research, piperine inhibits the inflammatory process, preventing weight loss damage to the tissues and diarrhea. (8,9)
Recently, posts warning sufferers of IBD, Crohn’s and Colitis not to consume piperine appeared in online forums. It was later found that an American company, which makes piperine-less products, was behind these claims. In light of this event it is important to emphasize that the amount of piperine needed to improve the bioavailability of curcumin or other herbal extracts is very minimal. CurcuminForte Balance® adheres to the Israeli Ministry of Health standard concerning piperine.
The Positive Effect of Pomegranate peel on Colitis
The medicinal properties of pomegranate derive from polyphenols, the active agents in pomegranate. The rind, which is hard and bitter making it unsuitable for eating, contains 10 times more active agents than the other parts of the fruit. The rind is also rich with ellagic acid, a very powerful anti-inflammatory and anti-oxidant. Consequently we use pomegranate rind extract in our formula.
How does the Ellagic acid influence Colitis?
The answer is found in the findings of two different research studies that examined the influence of ellagic acid on the reduction of the inflammation and ulcers in ulcerative colitis.
A research study [2002) conducted by scientists from the pharmaceutical school of the university of Tokyo Japan showed that treating rats that had ulcerative colitis with ellagic acid significantly reduced the intensity of inflammation.
Another research about the effect of ellagic acid on mice with ulcerative colitis was conducted at the University of Punjab, India. The mice were treated with ellagic acid extracted from pomegranate.
The findings of the study showed a significant reduction of the inflammation. What’s even more interesting is that the researchers found that the anti-ulcer activity of ellagic acid was equal to that of sulfasalazine or of Sodium Cromoglycate (which are standard, preventative inflammatory drugs).
The researchers ascribed the improvement of the ulcer to the ellagic acid's ability to stabilize the mast cells (white cells that protect the body) and to its antioxidative and anti-inflammatory properties.
Both teams reached the conclusion that ellagic acid significantly reduces inflammation and contributes to the cure of the ulcer, thanks to its antioxidant effect.
The connection between bowels bacteria and bowels inflammations
According to a research, carried out by a group of researchers from several hospitals in the U.S.A in 2015, the polyphenols in pomegranate peel extract increased the number of good bacteria such as Bifidobacterium and lactobacilus and significantly reduced anaerobic bacteria (bad bacteria). This means that pomegranate rind extract is prebiotic, it nourishes the good bacetria.
The researchers indicated that the polyphenol, which contributed to the increase in the number of the good bacteria, was ellagic acid.
According to these two studies pomegranate rind extract increases the number of good bacteria in the bowels and contributes to decreasing the cholesterol level and reducing bowel inflammation.
The synergy between curcumin and ellagic acid (pomegranate peel extract) increases significantly the efficiency of CurcuminForte Balance® formula in helping the immune system to inhibit inflammations.
For more information or to place an order for CurcuminForte Balance contact our Customers Service Representative on: +972-9-740-2584, +972-9-742-5114
If we are out of office leave, please a leave a message or send us an email with your name and telephone number. Our email is firstname.lastname@example.org. We will contact you ASAP.
Q1. What is the recommended dose of CurcuminForte Balance® and when to take it?
The recommended dose is one capsule a day unless your doctor recommended otherwise. One can take it at your comfort, but it has to be with food, not to skip a day, and preferred at the same time, all to intensify its effect.
Q2. After how long one can feel an improvement?
Herbs start acting from day one, but its influence one can feel only after a few weeks. That's the nature of herbs. Since people are different from each other, some will feel better after 2 months while others will feel an improvement only after 3 months.
Q3. How is the improvement being manifested?
The patient will have less severe symptoms during the active period of the disease and will have longer recessed period. Colitis patients who take our product claim that it helps them a lot coping with the disease and improves their life quality.
Q4. How long does one have to take the capsules ?
It is recommended to take it for as long as you can in order to preserve the recessed period longer.
All information published on this site is for information only. If you require medical advice we encourage you to speak to your doctor.
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- Pawel Kiela & Fayez K. Ghishan. "Curcumin May be Viable Supplement to Treat Inflammatory Bowel Disease (IBD)." The university of Arizaona. Arizona health sciences center. July 2009
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